1- What is Osteoarthritis?
Osteoarthritis is a chronic inflammatory illness that affects the joints. It causes cartilage loss, joint inflammation and swelling. It is normally located in the knees, hips, hands and spinal chord but particularly affects weight-supporting body parts.
2- What are osteoarthritis symptoms?
Osteoarthritis causes pain, stiffness (in the morning or after a long period of inactivity), and swelling. In advanced stages joints can be deformed, leading the patient to no longer execute certain movements normally, like walking or going upstairs, for example.
3- Is it osteoarthritis only a condition of the elderly?
Osteoarthritis cannot be cured. The existing oral treatments are intended to alleviate symptoms, improve mobility of the joint and slow down the progression of osteoarthritis.
5- What are the main medications for osteoarthritis?
Analgesic and anti-inflammatory drugs: they alleviate pain quickly but are not capable of changing the disease's development, as the symptoms reappear once the treatment stops. Chondroprotectors: chondroitin sulfate, glucosamine and hyaluronic acid. Chondroprotectors have a slow symptomatic action and have a demonstrated symptomatic efficacy similar to that of anti-inflammatory drugs (they alleviate pain and improve mobility). In addition they can slow down the degenerative process in the joints.
6- What are chondroprotectors?
Chondroprotectors are substances of natural origin that act to protect the joint. This pharmacological group encompasses the drugs targeted to preserving the integrity of joint, and therefore to slowing the progression of osteoarthritis. The main chondroprotectors are chondroitin sulfate, glucosamine and hyaluronic acid.
7- What about the safety of the medications for osteoarthritis?
Analgesic and anti-inflammatory drugs: they may entail safety problems (gastro-intestinal, cardiovascular, liver and kidney) and have interaction problems with other medicines. Chondroprotectors: as they are substances of natural origin, they are very safe and they do not have side effects. Additionally, they are not metabolized in the same way that other drugs and therefore cannot interact with them.
8- Can osteoarthritis medication be taken long term?
Because of their side effects and interactions, analgesic and anti-inflammatory drugs might not be recommended as chronic treatments. Chondroprotectors are the better option for a chronic treatment due to their excellent safety profile, with no side effects and no interactions with other drugs.
9- What is chondroitin sulfate?
It is one of the most important structural components of most connective tissues of the body such as cartilage, skin, blood vessels, as well as ligaments and tendons. Chondroitin sulfate can be obtained by a process of extraction and purification from animal cartilage. It is being used as a medicinal substance for the treatment of osteoarthritis and other joint conditions.
10- What are the effects of chondroitin sulfate in osteoarthritis?
Chondroitin sulfate, based on several randomized controlled clinical trials, has shown to be effective compared to placebo or anti-inflammatory drugs for pain relief and improvement of functional disability in patients with osteoarthritis. Moreover, it has also demonstrated to slow down the progression of the disease.
11- How long does it take to show its effect?
Chondroitin sulfate is characterized by a slow acting set of action. It normally takes 2-3 weeks to show its effect.
12- Is Chondroitin Sulfate recommended to treat osteoarthritis by the international guidelines?
Chondroitin sulfate is recommended as the baseline treatment for osteoarthritis by the most important guidelines in Rheumatology: In the EULAR Guidelines chondroitin sulfate has the maximum grade of recommendation (A). ESCEO Guidelines recommend chondroitin as background treatment for osteoarthritis. It is recommended as chronic prescription option in the first step of a proposed algorithm for the treatment of knee osteoarthritis.
13- What is the level of clinical evidence of chondroitin sulfate?
The clinical efficacy of chondroitin sulfate has been widely demonstrated. Recently the Cochrane Collaboration (a global independent network of researchers, professionals, patients, carers, and people interested in health) published a new revision on chondroitin sulfate in the Cochrane Library, and the conclusion from this comprehensive review of studies published to date was that chondroitin sulfate has a positive effect treating the symptoms and the progression of osteoarthritis.
14- What is CS b-Bioactive®
CS b-Bioactive® is Bioiberica's chondroitin sulfate, the most researched brand of chondroitin sulfate on the market. Has CS b-Bioactive® been tested in clinical trials? CS b-Bioactive® has been tested in 20 randomized clinical trials involving more than 5.000 patients. The results of these clinical trials demonstrate that CS b-Bioactive® reduces joint pain and improves mobility. It can also slow down the progression of osteoarthritis and recent studies suggest that it reduces the need for knee prosthesis implants.
15- What is the difference between CS b-Bioactive® and the rest of chondroitin sulfates?
Different manufacturing processes and different sources of biological starting material can give rise to chondroitin sulfate molecules with very different chemical-structural properties. The great variability that exists between different chondroitin sulfate molecules can affect the efficacy of the end product. Similarly, this variability can also affect the safety of the end product and may even have negative effects on the joint, such as inflammation, and cause allergic reactions in the organism, or have other more serious safety problems. CS b-Bioactive is being manufactured using the highest quality raw materials, which, together with an specific manufacturing method, guarantees the quality and the consistency of the molecule.
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