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The journal Annals of the Rheumatic Diseases confirms the efficacy of combined therapy with chondroitin sulfate plus glucosamine in knee osteoarthritis

  • The results of the clinical trial MOVES have been published showing that the combination of these two active ingredients reduces pain, functional disability, joint stiffness, swelling and effusion in knee osteoarthritis

  • It is an efficacy comparable to an anti-inflammatory drug after six months of treatment in severe osteoarthritis, but with a greater safety profile
  • 606 patients with primary knee osteoarthritis and moderate to severe pain from 42 centers in Spain, Germany, France and Poland participated in the study
  • The product tested in the study has been developed by Bioiberica and it is the only combination chondroitin sulfate – glucosamine authorized as drug in Europe.

The journal Annals of the Rheumatic Diseases (the highest impact journal in rheumatology worldwide with an impact factor of 9.270) has just published in its online edition the results of the clinical trial MOVES (Multicentre Osteoarthritis InterVEntion trial with Sysadoa). The main conclusion of the study is that the combination of chondroitin sulfate plus glucosamine has comparable efficacy to the anti-inflammatory drug celecoxib after six months of treatment in severe osteoarthritis. Specifically, it was seen that the combination of these two  active ingredients caused a clinically relevant reduction in pain, functional disability, stiffness, swelling and joint effusion, improving all the parameters studied:

 

  • Reduction in pain: 50.1%[1].
  • Reduction in functional disability: 45.5%.
  • Reduction in stiffness: 46.9%.
  • Reduction in swelling: 53%.
  • Reduction in joint effusion: 56%.

 

“This study confirms the efficacy of the combination of pharmaceutical grade-chondroitin sulfate and glucosamine in the long term and suggests that, considering its excellent safety profile, it may be a good alternative for patients with cardiovascular or gastrointestinal problems, for whom chronic treatment with NSAIDs cannot be recommended” explained Prof. Marc C. Hochberg, rheumatologist of the University of Maryland School of Medicine (Baltimore, USA) and member of the study's scientific committee.

 

Study design

MOVES is a multicenter, randomized, parallel-group, double-blind, controlled clinical trial, sponsored by Bioibérica, in which 606 patients with primary knee osteoarthritis and moderate to severe pain were recruited from 42 centers in Spain, Germany, France and Poland. A multidisciplinary team of investigators including rheumatologists, orthopaedists and primary care physicians participated in the study.

The primary objective was to show that the combination of chondroitin sulfate plus glucosamine is comparable in efficacy to celecoxib in the treatment of moderate to severe pain in patients with knee osteoarthritis. Patients were given pharmaceutical grade chondroitin sulfate (1200 mg/day) and glucosamine hydrochloride (1500 mg/ day) or 200 mg of celecoxib (anti-inflammatory drug) daily for six months.

The results confirmed those obtained in the GAIT study by Clegg's group in 2006 and published in the New England Journal of Medicine[2], where the combination was superior to placebo in patients with moderate to severe pain. “In fact, MOVES was developed as an extension from GAIT, to confirm these results. Since GAIT compared the combination versus celecoxib and placebo, the MOVES trial was designed as a non-inferiority study comparing only the combination versus celecoxib”, stated Prof. Allen Sawitzke, rheumatologist of the University of Utah School of Medicine (Salt Lake City, USA) who participated in the design of the two studies.

 

These results provide final confirmation of the efficacy and safety of the combination of chondroitin sulfate plus glucosamine for the treatment of knee osteoarthritis.

 

The pharmaceutical grade chondroitin sulfate used in both studies is produced by Bioiberica and is marketed as active ingredient under the brand CS b-Bioactive®

 

Chondroitin sulfate is a biological origin molecule, and therefore it has different physicochemical properties depending on the origin, purity and manufacturing process.

 

Bioiberica’s, chondroitin sulfate, CS b-Bioactive®, manufactured under strict pharmaceutical standards and with the highest purity in the market is the only chondroitin that has consistently demonstrated its clinical efficacy.

 

The MOVES study adds to the growing body of clinical evidence that makes CS b-Bioactive®  the most researched brand of chondroitin.

 

[1] From 20%, the reduction is considered clinically relevant.

[2] Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. Clegg DO, Reda DJ, Harris CL, Klein MA, O'Dell JR, Hooper MM et al. N Engl J Med. 2006 Feb 23;354(8):795-808.

 

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